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Indian J Pharmacol. 2014 Nov-Dec;46(6):579-83. doi: 10.4103/0253-7613.144891.

Endocan: a novel circulating proteoglycan.

Author information

1
Department of Microbiology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.
2
Department of Otorhinolaryngology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.

Abstract

Endocan is a novel endothelium derived soluble dermatan sulfate proteoglycan. It has the property of binding to a wide range of bioactive molecules associated with cellular signaling and adhesion and thus regulating proliferation, differentiation, migration, and adhesion of different cell types in health and disease. An increase in tissue expression or serum level of endocan reflects endothelial activation and neovascularization which are prominent pathophysiological changes associated with inflammation and tumor progression. Consequently, endocan has been used as a blood-based and tissue-based biomarker for various cancers and inflammation and has shown promising results.

KEYWORDS:

Cancer; endocan; endothelial cell-specific molecule; proteoglycan

PMID:
25538326
PMCID:
PMC4264070
DOI:
10.4103/0253-7613.144891
[Indexed for MEDLINE]
Free PMC Article

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