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J Int Med Res. 2015 Feb;43(1):54-66. doi: 10.1177/0300060514558324. Epub 2014 Dec 23.

Burnout: evaluation of the efficacy and tolerability of TARGET 1® for professional fatigue syndrome (burnout).

Author information

1
Department of Clinical Pharmacology, University of Bordeaux Ségalen, Bordeaux, France docteur.alain.jacquet@wanadoo.fr.
2
Department of Clinical Pharmacology, University of Bordeaux Ségalen, Bordeaux, France INSERM CIC-P0005, Bordeaux, France.
3
INSERM CIC-P0005, Bordeaux, France ADERA, Pessac, France.
4
Department of Clinical Pharmacology, University of Bordeaux Ségalen, Bordeaux, France INSERM CIC-P0005, Bordeaux, France INSERM U657, Bordeaux, France.

Abstract

OBJECTIVE:

To study the effect of a dietary supplement (TARGET 1®: a combination of casozepine, taurine, Eleutherococcus senticosus and extramel) on burnout symptomatology.

METHODS:

A 12-week, double-blind, randomized, placebo-controlled trial was conducted in workers engaged in professional contact with patients, students or clients. All were affected by burnout syndrome based on a score of ≥4 on the Burnout Measure Scale (BMS-10). The primary outcome measure was the change in the BMS-10 score; secondary outcome measures included the change in the Maslach's Burnout Inventory scale-Human Service Survey (MBI-HSS) score and the Beck Depression Inventory. Five scores were evaluated.

RESULTS:

Eighty-seven participants were enrolled in the study: 44 received the active formulation (verum group); 43 received placebo. After 12 weeks' supplementation, the placebo group showed significant improvements in scores for BMS-10, MBI-HSS fatigue and the Beck Depression Inventory, but MBI-HSS depersonalization and task management were not improved; the verum group showed significant improvements in all five scores. The verum group consistently showed significantly greater improvements in scores than the placebo group.

CONCLUSIONS:

TARGET 1® significantly improved the symptoms of burnout after 12 weeks' use.

KEYWORDS:

Burnout; TARGET 1®; dietary supplement; professional fatigue

PMID:
25537278
DOI:
10.1177/0300060514558324
[Indexed for MEDLINE]

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