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Med Sci (Paris). 2014 Dec;30(12):1161-8. doi: 10.1051/medsci/20143012020. Epub 2014 Dec 24.

[Chemobiology at happy hour: yeast as a model for pharmacological screening].

[Article in French]

Author information

1
Inserm UMR 1078 ; Université de Bretagne occidentale, Faculté de médecine et des sciences de la santé ; Établissement français du sang (EFS) ; CHRU Brest, hôpital Morvan, laboratoire de génétique moléculaire, 22, avenue Camille Desmoulins 29200 Brest, France.

Abstract

Since its discovery and description by Louis Pasteur, the budding yeast Saccharomyces cerevisiae, which was used for thousands of years for alcoholic fermentation and as a leavening agent, has become a popular model system in biology. One of the reasons for this popularity is the strong conservation from yeast to human of most of the pathways controlling cell growth and fate. In addition, at least 30 % of human genes involved in diseases have a functional homolog in yeast. Hence, yeast is now widely used for modelling and deciphering physiopathological mechanisms as well as for developing pharmacological approaches like phenotype-based drug screening. Three examples of such yeast-based chemobiological studies are presented.

PMID:
25537047
DOI:
10.1051/medsci/20143012020
[Indexed for MEDLINE]
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