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Biomarkers. 2015 Feb;20(1):89-94. doi: 10.3109/1354750X.2014.994564. Epub 2014 Dec 24.

Serum autotaxin levels correlate with hepatic dysfunction and severity in postoperative biliary atresia.

Author information

1
Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok , Thailand .

Abstract

OBJECTIVE:

To investigate correlation of serum autotaxin and disease severity in biliary atresia (BA).

METHODS:

Eighty postoperative BA patients and 15 controls were recruited. Serum autotaxin levels were determined by enzyme-linked immunosorbent assay.

RESULTS:

BA patients had greater serum autotaxin and liver stiffness than controls. Serum autotaxin and liver stiffness were markedly elevated in BA patients with jaundice compared to those without jaundice. Furthermore, serum autotaxin was correlated with liver stiffness and biochemical parameters in BA.

CONCLUSIONS:

Elevated serum autotaxin was correlated with hepatic dysfunction in BA. Accordingly, serum autotaxin is a promising biomarker reflecting the severity in BA.

KEYWORDS:

Autotaxin; biliary atresia; jaundice; liver stiffness; severity

PMID:
25536867
DOI:
10.3109/1354750X.2014.994564
[Indexed for MEDLINE]

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