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Psychiatry Res. 2015 Feb 28;225(3):489-92. doi: 10.1016/j.psychres.2014.11.061. Epub 2014 Dec 9.

The role of the potassium channel gene KCNK2 in major depressive disorder.

Author information

1
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
2
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. Electronic address: alessandra.minelli@unibs.it.
3
Genetic Unit, I.R.C.C.S. "San Giovanni di Dio" - Fatebenefratelli, Brescia, Italy.
4
Psychiatric Hospital "Villa Santa Chiara", Verona, Italy.
5
Department of Philosophy, Education, Psychology, University of Verona, Verona, Italy.
6
S.C.D.U. Psychiatric Service, AOU San Luigi Gonzaga, University of Turin, Orbassano (TO), Italy.
7
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy; Genetic Unit, I.R.C.C.S. "San Giovanni di Dio" - Fatebenefratelli, Brescia, Italy.

Abstract

Six single nucleotide polymorphisms (SNPs) of the KCNK2 gene were investigated for their association with major depressive disorder (MDD) and treatment efficacy in 590 MDD patients and 441 controls. The A homozygotes of rs10779646 were significantly more frequent in patients than controls whereas G allele of rs7549184 was associated with the presence of psychotic symptoms and the severity of disease. Evaluating the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) dataset, we confirmed our findings.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00021528.

KEYWORDS:

KCNK2; Major depressive disorder; Psychotic symptoms

PMID:
25535009
DOI:
10.1016/j.psychres.2014.11.061
[Indexed for MEDLINE]
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