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Nat Rev Immunol. 2015 Jan;15(1):30-44. doi: 10.1038/nri3785.

Periodontitis: from microbial immune subversion to systemic inflammation.

Author information

1
Department of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Abstract

Periodontitis is a dysbiotic inflammatory disease with an adverse impact on systemic health. Recent studies have provided insights into the emergence and persistence of dysbiotic oral microbial communities that can mediate inflammatory pathology at local as well as distant sites. This Review discusses the mechanisms of microbial immune subversion that tip the balance from homeostasis to disease in oral or extra-oral sites.

PMID:
25534621
PMCID:
PMC4276050
DOI:
10.1038/nri3785
[Indexed for MEDLINE]
Free PMC Article
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