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Brain Stimul. 2015 Mar-Apr;8(2):224-30. doi: 10.1016/j.brs.2014.11.005. Epub 2014 Nov 15.

TMS enhances retention of a motor skill in Parkinson's disease.

Author information

1
Department of Physiology, Pharmacology & Neuroscience, CUNY Medical School, New York, NY 10031, USA.
2
Department of Neurology, Movement Disorders Center, NYU-Langone School of Medicine, New York, NY 10016, USA.
3
Department of Neurosciences, Ophthalmology and Genetics, University of Genova, 16132, Italy.
4
Department of Physiology, Pharmacology & Neuroscience, CUNY Medical School, New York, NY 10031, USA; Department of Neurology, Movement Disorders Center, NYU-Langone School of Medicine, New York, NY 10016, USA; Department of Neurosciences, Psychiatry and Anaesthesiological Sciences, University of Messina, Messina, 98125, Italy.
5
Department of Psychiatry, University of Madison, WI 53719, USA.
6
Department of Physiology, Pharmacology & Neuroscience, CUNY Medical School, New York, NY 10031, USA; Department of Neurology, Movement Disorders Center, NYU-Langone School of Medicine, New York, NY 10016, USA. Electronic address: lice.mg79@gmail.com.

Abstract

BACKGROUND:

In Parkinson's disease (PD), skill retention is poor, even when acquisition rate is generally preserved. Recent work in normal subjects suggests that 5 Hz-repetitive transcranial magnetic stimulation (5Hz-rTMS) may induce phenomena of long-term potentiation at the cortical level.

OBJECTIVE/HYPOTHESIS:

We thus verified whether, in PD, 5Hz-rTMS enhances retention of a visuo-motor skill that involves the activity of the right posterior parietal cortex.

METHODS:

A group of patients with PD was tested in two two-day sessions, separated by one week (treatment and placebo sessions). The first day of each session, they learned to adapt their movements to a step-wise 60° visual rotation. Immediately after the task, either real 5Hz-rTMS (treatment) or sham (placebo) stimulation was applied over the right posterior parietal cortex (P6). Retention of this motor skill was tested the following day.

RESULTS:

In patients with PD, adaptation achieved at the end of training was comparable in the treatment and placebo sessions and was similar to that of a group of age-matched controls. However, retention indices tested on the following day were significantly lower in the placebo compared to the treatment session in which retention indices were restored to the level of the controls. Importantly, reaction and movement time as well as other kinematic measures were the same in the treatment and placebo sessions.

CONCLUSION:

These results suggest that rTMS applied after the acquisition of a motor skill over specific areas involved in this process might enhance skill retention in PD.

KEYWORDS:

Adaptation; Consolidation; Motor learning; Motor skills

PMID:
25533243
PMCID:
PMC4314317
DOI:
10.1016/j.brs.2014.11.005
[Indexed for MEDLINE]
Free PMC Article

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