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Nutrients. 2014 Dec 22;6(12):5992-6004. doi: 10.3390/nu6125992.

Effects of levocarnitine on brachial-ankle pulse wave velocity in hemodialysis patients: a randomized controlled trial.

Author information

1
Department of Nephrology, Keiai Hospital, Tokyo 173-0036, Japan. thiguchi@keiai-hospital.jp.
2
Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan. abe.masanori@nihon-u.ac.jp.
3
Department of Nephrology, Keiai Hospital, Tokyo 173-0036, Japan. zakio@keiai-hospital.jp.
4
Department of Nephrology, Keiai Hospital, Tokyo 173-0036, Japan. mari@keiai-hospital.jp.
5
Department of Nephrology, Keiai Hospital, Tokyo 173-0036, Japan. erina@keiai-hospital.jp.
6
Department of Cardiology, Keiai Hospital, Tokyo 173-0036, Japan. ando@keiai-hospital.jp.
7
Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan. oikawa.osamu@nihon-u.ac.jp.
8
Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan. kokada@med.nihon-u.ac.jp.
9
Department of Nephrology, Meirikai Chuo General Hospital, Tokyo 114-0001, Japan. fkikuchi@ims.or.jp.
10
Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo 173-8610, Japan. souma.masayoshi@nihon-u.ac.jp.

Abstract

BACKGROUND AND AIMS:

Atherosclerotic cardiovascular disease is the most common cause of mortality in patients with end-stage kidney disease. Chronic kidney disease patients often exhibit a deficiency in L-carnitine due to loss during hemodialysis (HD). We studied the effects of L-carnitine supplementation on brachial-ankle pulse wave velocity (baPWV), a marker of atherosclerosis, in HD patients.

METHODS:

This was a prospective, open-label, randomized, parallel controlled, multi-center trial testing the anti-atherosclerotic efficacy of oral L-carnitine administration (20 mg/kg/day). HD patients (n = 176, mean age, 67.2 ± 10.3 years old; mean duration of HD, 54 ± 51 months) with plasma free L-carnitine deficiency (<40 μmol/L) were randomly assigned to the oral L-carnitine group (n = 88) or control group (n = 88) and monitored during 12 months of treatment.

RESULTS:

There were no significant differences in baseline clinical variables between the L-carnitine and control groups. L-carnitine supplementation for 12 months significantly increased total, free, and acyl carnitine levels, and reduced the acyl/free carnitine ratio. The baPWV value decreased from 2085 ± 478 cm/s at baseline to 1972 ± 440 cm/s after six months (p < 0.05) to 1933 ± 363 cm/s after 12 months (p < 0.001) of L-carnitine administration, while no significant changes in baPWV were observed in the control group. Baseline baPWV was the only factor significantly correlated with the decrease in baPWV.

CONCLUSIONS:

L-carnitine supplementation significantly reduced baPWV in HD patients. L-carnitine may be a novel therapeutic strategy for preventing the progression of atherosclerotic cardiovascular disease.

PMID:
25533009
PMCID:
PMC4277011
DOI:
10.3390/nu6125992
[Indexed for MEDLINE]
Free PMC Article

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