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Acta Physiol Hung. 2014 Dec;101(4):429-37. doi: 10.1556/APhysiol.101.2014.4.4.

Orally given gastroprotective capsaicin does not modify aspirin-induced platelet aggregation in healthy male volunteers (human phase I examination).

Author information

1
University of Pécs, School of Medicine 1st Department of Medicine Rákóczi út 2 H-7623 Pécs Hungary.
2
University of Pécs, School of Medicine Department of Pharmacology and Pharmacotherapy Pécs Hungary.

Abstract

Capsaicin is a well-known component of red pepper. Recent studies have shown that capsaicin could prevent gastric ulcer provoked by various NSAID-s like acetylsalicylic acid (ASA). Primary objective of this human clinical phase I trial was to investigate whether two different doses of capsaicin co-administered with ASA could alter the inhibitory effect of ASA on platelet aggregation. 15 healthy male subjects were involved in the study and treated orally with 400 μg capsaicin, 800 μg capsaicin, 500 mg ASA, 400 μg capsaicin+500 mg ASA and 800 μg capsaicin+500 mg ASA. Blood was drawn before and 1, 2, 6 and 24 hours after the drug administration. After that epinephrine induced platelet aggregation was measured by optical aggregometry. Between treatments, volunteers had a 6-day wash-out period. Our results showed that capsaicin had no effect on platelet aggregation, while as expected, ASA monotherapy resulted in a significant and clinically effective platelet aggregation inhibition (p ≤ 0.001). The combined ASA-capsaicin therapies reached equivalent effectiveness in platelet aggregation inhibition as ASA monotherapy. Our investigation proved that capsaicin did not influence the inhibitory effect of ASA on platelet aggregation, thus the capsaicin-ASA treatment would combine the antiplatelet effect of ASA with the possible gastroprotection of capsaicin.

KEYWORDS:

acetylsalicylic acid; capsaicin; gastric mucosal lesion; healthy volunteers; platelet aggregation

PMID:
25532954
DOI:
10.1556/APhysiol.101.2014.4.4
[Indexed for MEDLINE]

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