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Head Neck. 2016 Apr;38 Suppl 1:E189-97. doi: 10.1002/hed.23969. Epub 2015 Jun 24.

MicroRNA expression as predictor of local recurrence risk in oral squamous cell carcinoma.

Author information

1
Translational Oncogenomics Unit, Italian National Cancer Institute "Regina Elena", Rome, Italy.
2
Otolaryngology Department, Italian National Cancer Institute "Regina Elena", Rome, Italy.
3
Biostatistical Unit, Italian National Cancer Institute "Regina Elena", Rome, Italy.
4
Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
5
Pathology Department, Italian National Cancer Institute "Regina Elena", Rome, Italy.
6
Department of Oncology, Juravinski Cancer Center-McMaster University Hamilton, Ontario, Canada.
7
School of Public Health-Harvard University, Boston, Massachusetts.
8
Molecular Chemoprevention Unit, Italian National Cancer Institute "Regina Elena", Rome, Italy.

Abstract

BACKGROUND:

Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide with a high rate of recurrence. MicroRNAs (miRNAs) are gene regulators playing an important role in oral carcinogenesis. The purpose of this study was for us to identify and functionally characterize miRNAs that predict recurrence in OSCC.

METHODS:

We collected 92 OSCC with their normal tissue counterparts and we performed miRNAs expression profiling on 74 OSCC and 38 normal tissues. The association between the expression of miRNAs and clinical outcome was evaluated in the follow-up of 69 patients.

RESULTS:

Four of the miRNAs deregulated between OSCC and normal tissues are prognostic for recurrence either when considered individually or as a group. Depletion of the expression of prognostic miRNAs inhibit the proliferation of OSCC cells

CONCLUSION:

MiRNAs are differentially expressed in OSCC versus normal samples. The expression of 4 prognostic miRNA signatures is able to predict recurrence risk independently from other clinical factors in OSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E189-E197, 2016.

KEYWORDS:

microRNA; oral squamous cell carcinoma (OSCC); prognosis; recurrence; signature

PMID:
25532855
DOI:
10.1002/hed.23969
[Indexed for MEDLINE]

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