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Mol Pharm. 2015 Feb 2;12(2):314-21. doi: 10.1021/mp500656v. Epub 2015 Jan 7.

Smart polymeric nanoparticles for cancer gene delivery.

Author information

1
School of Pharmaceutical Science, Shandong University , Jinan 250012, China.

Abstract

The massive amount of human genetic information already available has accelerated the identification of target genes, making gene and nucleic acid therapy the next generation of medicine. Nanoparticle (NP)-based anticancer gene therapy treatment has received significant interest in this evolving field. Recent advances in vector technology have improved gene transfection efficiencies of nonviral vectors to a level similar to viruses. This review serves as an introduction to surface modifications of NPs based on polymeric structural improvements and target moieties. A discussion regarding the future perspective of multifunctional NPs in cancer therapy is also included.

KEYWORDS:

cancer therapy; gene delivery; nanoparticle

PMID:
25531409
PMCID:
PMC4319689
DOI:
10.1021/mp500656v
[Indexed for MEDLINE]
Free PMC Article

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