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Nat Rev Mol Cell Biol. 2015 Jan;16(1):18-29. doi: 10.1038/nrm3920.

Intrinsically disordered proteins in cellular signalling and regulation.

Author information

1
Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Abstract

Intrinsically disordered proteins (IDPs) are important components of the cellular signalling machinery, allowing the same polypeptide to undertake different interactions with different consequences. IDPs are subject to combinatorial post-translational modifications and alternative splicing, adding complexity to regulatory networks and providing a mechanism for tissue-specific signalling. These proteins participate in the assembly of signalling complexes and in the dynamic self-assembly of membrane-less nuclear and cytoplasmic organelles. Experimental, computational and bioinformatic analyses combine to identify and characterize disordered regions of proteins, leading to a greater appreciation of their widespread roles in biological processes.

PMID:
25531225
PMCID:
PMC4405151
DOI:
10.1038/nrm3920
[Indexed for MEDLINE]
Free PMC Article

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