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Cell Biochem Funct. 2015 Jan;33(1):1-13. doi: 10.1002/cbf.3086. Epub 2014 Dec 22.

The role of nuclear hormone receptors in cutaneous wound repair.

Author information

1
Center for Regenerative Biology and Medicine, MDI Biological Laboratory, Salisbury Cove, ME, USA.

Abstract

The cutaneous wound repair process involves balancing a dynamic series of events ranging from inflammation, oxidative stress, cell migration, proliferation, survival and differentiation. A complex series of secreted trophic factors, cytokines, surface and intracellular proteins are expressed in a temporospatial manner to restore skin integrity after wounding. Impaired initiation, maintenance or termination of the tissue repair processes can lead to perturbed healing, necrosis, fibrosis or even cancer. Nuclear hormone receptors (NHRs) in the cutaneous environment regulate tissue repair processes such as fibroplasia and angiogenesis. Defects in functional NHRs and their ligands are associated with the clinical phenotypes of chronic non-healing wounds and skin endocrine disorders. The functional relationship between NHRs and skin niche cells such as epidermal keratinocytes and dermal fibroblasts is pivotal for successful wound closure and permanent repair. The aim of this review is to delineate the cutaneous effects and cross-talk of various nuclear receptors upon injury towards functional tissue restoration.

KEYWORDS:

hormones; innervation; keratinocytes; nuclear receptors; regeneration; tissue repair; vitamin D; wound healing

PMID:
25529612
PMCID:
PMC4357276
DOI:
10.1002/cbf.3086
[Indexed for MEDLINE]
Free PMC Article

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