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Biol Blood Marrow Transplant. 2015 Mar;21(3):389-401.e1. doi: 10.1016/j.bbmt.2014.12.001. Epub 2014 Dec 18.

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.

Author information

1
Department of Hematology and Oncology, Vanderbilt University Medical Center, Nashville, Tennessee.
2
Department of Internal Medicine, Medical University of Vienna, Vienna, Austria.
3
Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
4
Center for Cancer Research National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Department of Blood and Marrow Transplantation, Children's National Health System, Washington, District of Columbia.
5
Department of Internal Medicine, University of Regensburg, Regensburg, Germany.
6
Center for Cancer Research National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
7
Department of Hematology Oncology/Blood and Marrow Transplant, Mayo Clinic Arizona, Phoenix, Arizona.
8
Department of Surgery, Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, Massachusetts.
9
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
10
Hematology Department, BC Cancer Agency, Vancouver, British Columbia, Canada.
11
Pediatric and Reproductive Endocrinology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD.
12
Department of Hematology, Institut Catala d'Oncologia, Barcelona, Spain.
13
Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
14
Hematology and Hemotherapy Center, Hemocentro Unicamp, Campinas, Sao Paulo, Brazil.
15
Department of Blood and Marrow Transplantation, Stanford University Medical Center, Stanford, California.
16
The Eye Clinic, National Eye Institute, National Institutes of Health, Bethesda, Maryland.
17
Department of Blood and Marrow Transplantation, Children's National Health System, Washington, District of Columbia.
18
Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland.
19
Blood and Marrow Transplant Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan.
20
Department of Applied Research Cancer Control and Population Sciences, National Institutes of Health, Bethesda, Maryland.
21
Cancer Therapy Evaluation Program, National Institutes of Health, Bethesda, Maryland.
22
Division of Hematologic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
23
Oncology Department, Johns Hopkins University School of Medicine, Baltimore, Maryland.
24
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address: mflowers@fredhutch.org.

Abstract

The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD). The 2014 NIH consensus maintains the framework of the prior consensus with further refinement based on new evidence. Revisions have been made to address areas of controversy or confusion, such as the overlap chronic GVHD subcategory and the distinction between active disease and past tissue damage. Diagnostic criteria for involvement of mouth, eyes, genitalia, and lungs have been revised. Categories of chronic GVHD should be defined in ways that indicate prognosis, guide treatment, and define eligibility for clinical trials. Revisions have been made to focus attention on the causes of organ-specific abnormalities. Attribution of organ-specific abnormalities to chronic GVHD has been addressed. This paradigm shift provides greater specificity and more accurately measures the global burden of disease attributed to GVHD, and it will facilitate biomarker association studies.

KEYWORDS:

Chronic graft-versus-host disease; Diagnosis; National Institutes of Health; Staging

PMID:
25529383
PMCID:
PMC4329079
DOI:
10.1016/j.bbmt.2014.12.001
[Indexed for MEDLINE]
Free PMC Article
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