Format

Send to

Choose Destination
Trends Cardiovasc Med. 2015 May;25(4):278-87. doi: 10.1016/j.tcm.2014.11.006. Epub 2014 Nov 15.

Kruppel-like factors in muscle health and disease.

Author information

1
Case Cardiovascular Research Institute, Cleveland, OH; Harrington Heart & Vascular Institute, Cleveland, OH; Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH.
2
Case Cardiovascular Research Institute, Cleveland, OH; Harrington Heart & Vascular Institute, Cleveland, OH; Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH. Electronic address: mukesh.jain2@case.edu.

Abstract

Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. Emerging evidence suggests that KLFs are critical regulators of muscle biology in the context of cardiovascular health and disease. The focus of this review is to provide an overview of the current state of knowledge regarding the physiologic and pathologic roles of KLFs in the three lineages of muscle: cardiac, smooth, and skeletal.

Comment in

PMID:
25528994
PMCID:
PMC4422160
DOI:
10.1016/j.tcm.2014.11.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center