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J Allergy Clin Immunol. 2015 May;135(5):1199-206.e1-11. doi: 10.1016/j.jaci.2014.10.042. Epub 2014 Dec 18.

Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence.

Author information

1
Department of Clinical Science, Intervention and Technology, Division of Ear, Nose and Throat Diseases, Karolinska Institutet, Stockholm, Sweden; Department of Ear, Nose and Throat Diseases, Karolinska University Hospital, Stockholm, Sweden. Electronic address: marit.westman@ki.se.
2
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
3
University Hospital of Montpellier, Hôpital Arnaud de Villeneuve, Montpellier, INSERM 1018, Villejuif, France.
4
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
5
Department of Clinical Science, Intervention and Technology, Division of Ear, Nose and Throat Diseases, Karolinska Institutet, Stockholm, Sweden; Department of Ear, Nose and Throat Diseases, Karolinska University Hospital, Stockholm, Sweden.
6
Department of Pediatrics, University of Oslo, Oslo University Hospital, Oslo, Norway.
7
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; IMIM (Hospital del Mar Research Institute), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
8
Clinical Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet and University Hospital, Stockholm, Sweden.
9
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Sachs' Children's Hospital, Södersjukhuset, Stockholm, Sweden.

Abstract

BACKGROUND:

Component-resolved diagnosis might improve the prediction of future allergy in young children.

OBJECTIVE:

We sought to investigate the association between IgE reactivity to the pathogenesis-related class 10 (PR-10) protein family and allergic rhinitis to birch pollen (ARbp) from early childhood up to age 16 years.

METHOD:

Questionnaire data and sera obtained at 4, 8, and 16 years of age from the Barn/Children Allergi/Allergy Milieu Stockholm Epidemiologic (BAMSE) study birth cohort were used. Sera from 764 children were analyzed for IgE reactivity to 9 PR-10 allergen proteins at the 3 time points by using an allergen chip based on ISAC technology. ARbp was defined as upper airway symptoms during birch pollen exposure.

RESULTS:

IgE reactivity to Bet v 1 was found in 12%, 17%, and 25% of children at 4, 8, and 16 years of age. IgE reactivity of PR-10 proteins showed a hierarchic intrarelationship: Bet v 1 > Mal d 1 > Cor a 1.04 > Ara h 8 > Pru p 1 > Aln g 1 > Api g 1 > Act d 8 > Gly m 4. There was an increased risk of incidence and persistence of ARbp up to age 16 years with increasing levels of Bet v 1-specific IgE or increasing numbers of IgE-reactive PR-10 proteins at 4 years. Children with severe ARbp at age 16 years had higher levels of Bet v 1-specific IgE at age 4 years compared with children with mild symptoms.

CONCLUSION:

ARbp at age 16 years can be predicted by analysis of IgE reactivity to PR-10 proteins in early childhood.

KEYWORDS:

Allergen components; BAMSE; IgE; MeDALL; allergic rhinitis; birch pollen; cohort; cross-reactivity; microarray; oral allergy syndrome

PMID:
25528361
DOI:
10.1016/j.jaci.2014.10.042
[Indexed for MEDLINE]

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