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Osteoarthritis Cartilage. 2015 Mar;23(3):370-8. doi: 10.1016/j.joca.2014.12.008. Epub 2014 Dec 17.

The association between vitamin K status and knee osteoarthritis features in older adults: the Health, Aging and Body Composition Study.

Author information

1
USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. Electronic address: kyla.shea@tufts.edu.
2
Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, NC, USA.
3
Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
4
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
5
USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
6
Division of Rheumatology, University of Arizona, Tucson, AZ, USA.
7
Division of Rheumatology, Tufts Medical Center, Boston, MA, USA.
8
VitaK, Maastricht, The Netherlands.
9
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, USA.
10
Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
11
Division of Rheumatology, Allergy and Immunology, University of North Carolina, Chapel Hill, NC, USA.

Abstract

BACKGROUND:

Vitamin K-dependent (VKD) proteins, including the mineralization inhibitor matrix-gla protein (MGP), are found in joint tissues including cartilage and bone. Previous studies suggest low vitamin K status is associated with higher osteoarthritis (OA) prevalence and incidence.

OBJECTIVE:

To clarify what joint tissues vitamin K is relevant to in OA, we investigated the cross-sectional and longitudinal association between vitamin K status and knee OA structural features measured using magnetic resonance imaging (MRI).

METHODS:

Plasma phylloquinone (PK, vitamin K1) and dephosphorylated-uncarboxylated MGP ((dp)ucMGP) were measured in 791 older community-dwelling adults who had bilateral knee MRIs (mean ± SD age = 74 ± 3 y; 67% female). The adjusted odds ratios (and 95% confidence intervals) [OR (95%CI)] for presence and progression of knee OA features according to vitamin K status were calculated using marginal models with generalized estimating equations (GEEs), adjusted for age, sex, body mass index (BMI), triglycerides and other pertinent confounders.

RESULTS:

Longitudinally, participants with very low plasma PK (<0.2 nM) were more likely to have articular cartilage and meniscus damage progression after 3 years [OR (95% CIs): 1.7(1.0-3.0), 2.6(1.3-5.2) respectively] compared to sufficient PK (≥ 1.0 nM). Higher plasma (dp)ucMGP (reflective of lower vitamin K status) was associated with higher odds of meniscus damage, osteophytes, bone marrow lesions, and subarticular cysts cross-sectionally [ORs (95% CIs) comparing highest to lowest quartile: 1.6(1.1-2.3); 1.7(1.1-2.5); 1.9(1.3-2.8); 1.5(1.0-2.1), respectively].

CONCLUSION:

Community-dwelling men and women with very low plasma PK were more likely to have progression of articular cartilage and meniscus damage. Plasma (dp)ucMGP was associated with presence of knee OA features but not progression. Future studies are needed to clarify mechanisms underlying vitamin Ks role in OA.

KEYWORDS:

Epidemiology; Matrix gla protein; Nutrition; Osteoarthritis; Phylloquinone; Vitamin K

PMID:
25528106
PMCID:
PMC4339507
DOI:
10.1016/j.joca.2014.12.008
[Indexed for MEDLINE]
Free PMC Article

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