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Gene. 2015 Feb 25;557(2):113-22. doi: 10.1016/j.gene.2014.12.020. Epub 2014 Dec 17.

NEDD4: The founding member of a family of ubiquitin-protein ligases.

Author information

1
Centre for Cancer Biology, University of South Australia, Adelaide, SA 5001, Australia.
2
Centre for Cancer Biology, University of South Australia, Adelaide, SA 5001, Australia. Electronic address: sharad.kumar@health.sa.gov.au.

Abstract

Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is evolutionarily conserved in eukaryotes. Many potential substrates of NEDD4 have been identified and NEDD4 has been shown to play a critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumour suppressor PTEN. In this review we will discuss the diverse pathways in which NEDD4 is involved, and the patho-physiological significance of this important ubiquitin ligase.

KEYWORDS:

IGF signalling; NEDD4 family; PTEN; Ubiquitin; Ubiquitin protein ligases

PMID:
25527121
PMCID:
PMC6639052
DOI:
10.1016/j.gene.2014.12.020
[Indexed for MEDLINE]
Free PMC Article

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