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Genet Mol Res. 2014 Dec 18;13(4):10615-21. doi: 10.4238/2014.December.18.3.

Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population.

Author information

1
Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
2
Department of Urology, The First People's Hospital of Suqian, Suqian, China.
3
Department of Urology, 2nd Affliated Hospital of Nantong University, Nantong, China.
4
Department of Molecular and Genetic Toxicology, Cancer Center of Nanjing Medical University, Nanjing, China.
5
Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
6
Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China njxb1982@126.com.

Abstract

Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy. Seventy-two southern Chinese with prostate cancer undergoing radical prostatectomy were included in this study. miR-146a polymorphism was analyzed by PCR-RFLP. Its prognostic role in biochemical recurrence was assessed using Kaplan-Meier analysis and Cox regression model. We did not find a significant association between miR-146a polymorphism and prostrate-specific antigen failure in the Chinese population [HR (95%CI): 0.83 (0.30-2.32) for CC vs GG/GC]. However, high Gleason score (over 8) was associated with increased biochemical recurrence and poorer PSA-free survival. This study was limited by the length of follow-up. Future studies with longer follow-up would allow evaluation of more direct metrics, such as disease-specific survival, metastasis-free survival, and overall survival.

PMID:
25526182
DOI:
10.4238/2014.December.18.3
[Indexed for MEDLINE]
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