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Genet Mol Res. 2014 Dec 18;13(4):10615-21. doi: 10.4238/2014.December.18.3.

Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population.

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Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
Department of Urology, The First People's Hospital of Suqian, Suqian, China.
Department of Urology, 2nd Affliated Hospital of Nantong University, Nantong, China.
Department of Molecular and Genetic Toxicology, Cancer Center of Nanjing Medical University, Nanjing, China.
Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China


Evidence has shown that miR-146a is involved in carcinogenesis and a common G/C variant (rs2910164) in the pre-miR-146a gene has been found to be associated with various cancers. We investigated the potential prognostic role of miR-146a polymorphism in prostate cancer after radical prostatectomy. Seventy-two southern Chinese with prostate cancer undergoing radical prostatectomy were included in this study. miR-146a polymorphism was analyzed by PCR-RFLP. Its prognostic role in biochemical recurrence was assessed using Kaplan-Meier analysis and Cox regression model. We did not find a significant association between miR-146a polymorphism and prostrate-specific antigen failure in the Chinese population [HR (95%CI): 0.83 (0.30-2.32) for CC vs GG/GC]. However, high Gleason score (over 8) was associated with increased biochemical recurrence and poorer PSA-free survival. This study was limited by the length of follow-up. Future studies with longer follow-up would allow evaluation of more direct metrics, such as disease-specific survival, metastasis-free survival, and overall survival.

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