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Future Oncol. 2014 Dec;10(15):2459-68. doi: 10.2217/fon.14.180.

BMI variation increases recurrence risk in women with early-stage breast cancer.

Author information

1
Medical Oncology & Breast Unit, 'A Perrino' Hospital, SS 7 Appia, 72100 Brindisi, Italy.

Abstract

AIMS:

The prognostic role of BMI variation during and/or after treatments for early-stage breast cancer is still unknown.

PATIENTS & METHODS:

The χ(2) test was conducted to explore the correlation between breast cancer recurrence and BMI changes in 520 early-stage breast cancer patients. Cox proportional hazard models were used to analyze the association of BMI changes, baseline BMI, known prognostic factors and recurrences.

RESULTS:

BMI gain was significant determinant of recurrences (p = 0.0008). In multivariate analyses, BMI variation more than 5.71% was associated with higher rates of recurrences, as well as age less than 55 years, stage disease and molecular subtype.

CONCLUSION:

Women who experience BMI gain after breast cancer may be at increased risk of poor outcomes.

KEYWORDS:

BMI; early-stage breast cancer; recurrence; weight gain; weight loss

PMID:
25525854
DOI:
10.2217/fon.14.180
[Indexed for MEDLINE]

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