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Int J Nanomedicine. 2014 Dec 8;9:5753-69. doi: 10.2147/IJN.S73185. eCollection 2014.

Selective inhibition of liver cancer growth realized by the intrinsic toxicity of a quantum dot-lipid complex.

Author information

1
Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, People's Republic of China.
2
Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, the Netherlands.
3
Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, People's Republic of China ; School of Nursing, Jilin University, Changchun, People's Republic of China.

Abstract

Using the intrinsic toxicity of nanomaterials for anticancer therapy is an emerging concept. In this work, we discovered that CdTe/CdS quantum dots, when coated with lipids (QD-LC) instead of popular liposomes, polymers, or dendrimers, demonstrated extraordinarily high specificity for cancer cells, which was due to the difference in the macropinocytosis uptake pathways of QD-LC between the cancer cells and the normal cells. QD-LC-induced HepG2 cell apoptosis was concomitant with the activation of the JNK/caspase-3 signaling pathway. Moreover, QD-LC treatment resulted in a delay in the latent period for microtumor formation of mouse hepatocarcinoma H22 cells and inhibited tumor growth, with a reduction of 53.2% in tumor volume without toxicity in major organs after intratumoral administrations to tumor-bearing mice. Our results demonstrate that QD-LC could be a very promising theranostic agent against liver cancer.

KEYWORDS:

CdTe/CdS quantum dot-plipid complex; intrinsic nanotoxicity; liver cancer therapy; macropinocytosis; selectivity

PMID:
25525357
PMCID:
PMC4268910
DOI:
10.2147/IJN.S73185
[Indexed for MEDLINE]
Free PMC Article

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