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Cancer Prev Res (Phila). 2015 Jan;8(1):20-6. doi: 10.1158/1940-6207.CAPR-14-0250. Epub 2014 Dec 18.

Evidence supporting product standards for carcinogens in smokeless tobacco products.

Author information

1
University of Minnesota, Masonic Cancer Center, Minneapolis, Minnesota. Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota. hatsu001@umn.edu.
2
University of Minnesota, Masonic Cancer Center, Minneapolis, Minnesota.
3
Oregon Research Institute, Eugene, Oregon.
4
Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
5
George Washington University, School of Public Health, Washington, District of Columbia.
6
Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota.

Abstract

Smokeless tobacco products sold in the United States vary significantly in yields of nicotine and tobacco-specific nitrosamines (TSNA). With the passage of the Family Smoking Prevention and Tobacco Control Act, the Food and Drug Administration now has the authority to establish product standards. However, limited data exist determining the relative roles of pattern of smokeless tobacco use versus constituent levels in the smokeless tobacco product in exposure of users to carcinogens. In this study, smokeless tobacco users of brands varying in nicotine and TSNA content were recruited from three different regions in the U.S. Participants underwent two assessment sessions. During these sessions, demographic and smokeless tobacco use history information along with urine samples to assess biomarkers of exposure and effect were collected. During the time between data collection, smokeless tobacco users recorded the amount and duration of smokeless tobacco use on a daily basis using their diary cards. Results showed that independent of pattern of smokeless tobacco use and nicotine yields, levels of TSNA in smokeless tobacco products played a significant role in carcinogen exposure levels. Product standards for reducing levels of TSNA in smokeless tobacco products are necessary to decrease exposure to these toxicants and potentially to reduce risk for cancer.

PMID:
25524878
PMCID:
PMC4299753
DOI:
10.1158/1940-6207.CAPR-14-0250
[Indexed for MEDLINE]
Free PMC Article

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