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Cancer Lett. 2015 May 1;360(2):89-105. doi: 10.1016/j.canlet.2014.11.051. Epub 2014 Dec 15.

MicroRNAs in colorectal cancer: small molecules with big functions.

Author information

1
Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, China; The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
2
The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
3
Department of Emergency Medicine, Thomas Jefferson University Hospital, USA.
4
Department of Surgery, Emergency Medicine, Kaiser Santa Clara Medial Center, Affiliate of Stanford University, USA.
5
College of Biological Sciences, Sichuan University, Chengdu 610041, China.
6
Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, China.
7
Department of Gynecology and Obstetrics, Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, China. Electronic address: taotaovip2005@163.com.

Abstract

Colorectal cancer (CRC) is the third most lethal malignancy, with pathogenesis intricately dependent upon microRNAs (miRNAs). miRNAs are short, non-protein coding RNAs, targeting the 3'-untranslated regions (3'-UTR) of certain mRNAs. They usually serve as tumor suppressors or oncogenes, and participate in tumor phenotype maintenance. Therefore, miRNAs consequently regulate CRC carcinogenesis and other biological functions, including apoptosis, development, angiogenesis, migration, and proliferation. Due to its differential expression and distinct stability, miRNAs are regarded as molecular biomarkers (for diagnosis/prognosis) and therapeutic targets for CRC. Recently, a remarkable number of miRNAs have been discovered with implications via incompletely understood mechanisms in CRC. As further study of relevant miRNAs continues, it is hopeful that novel miRNA-based therapeutic strategies may be available for CRC patients in the future.

KEYWORDS:

Colorectal cancer; MicroRNA; Oncogene; Tumor suppressor

PMID:
25524553
DOI:
10.1016/j.canlet.2014.11.051
[Indexed for MEDLINE]

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