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Proteomics Clin Appl. 2015 Feb;9(1-2):221-34. doi: 10.1002/prca.201400101. Epub 2015 Jan 19.

Proteomics in the investigation of HIV-1 interactions with host proteins.

Author information

1
Laboratory of Retrovirology, Division of Infectious Diseases, Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.

Abstract

Productive HIV-1 infection depends on host machinery, including a broad array of cellular proteins. Proteomics has played a significant role in the discovery of HIV-1 host proteins. In this review, after a brief survey of the HIV-1 host proteins that were discovered by proteomic analyses, I focus on analyzing the interactions between the virion and host proteins, as well as the technologies and strategies used in those proteomic studies. With the help of proteomics, the identification and characterization of HIV-1 host proteins can be translated into novel antiretroviral therapeutics.

KEYWORDS:

Cellular factor; HIV-1; Host protein; MS; Viral protein

PMID:
25523935
PMCID:
PMC4424045
DOI:
10.1002/prca.201400101
[Indexed for MEDLINE]
Free PMC Article

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