Format

Send to

Choose Destination
Zhongguo Dang Dai Er Ke Za Zhi. 2014 Dec;16(12):1236-40.

[Effects of r-hGH replacement therapy on glucose and lipid metabolism and thyroid function in children with idiopathic short stature].

[Article in Chinese]

Author information

1
Peking University Third Hospital, Beijing 100191, China. xuemeiw7886@sohu.com.

Abstract

OBJECTIVE:

To study the effects of recombinant human growth hormone (r-hGH) replacement therapy on glucose and lipid metabolism and thyroid function in children with idiopathic short stature (ISS).

METHODS:

Forty-seven ISS children with a mean age of 10±3 years treated between January 2009 and January 2013 were enrolled. All children underwent r-hGH replacement therapy for 3-24 months and were followed up once every 3 months. Fasting blood glucose (FBG), insulin (INS), blood lipids and thyroid function were measured before treatment and after 0-1 and 1-2 years of treatment.

RESULTS:

After treatment with r-hGH, there were no significant changes in FBG, INS, insulin sensitivity index (ISI), and FBG/INS ratio (FGIR), but the FGIR showed a declining trend. The percentage of patients with FGIR<7 (a marker of insulin resistance) was 13% before treatment compared to 18% 1-2 years after treatment. The atherosclerosis index decreased after r-hGH treatment, but there were no significant changes in total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and BMI. Furthermore, no significant change in thyroid function was observed after r-hGH therapy.

CONCLUSIONS:

r-hGH therapy can improve lipid metabolism, without significant impacts on thyroid function, FBG and INS. It seems to be a safe and reliable therapy for children with ISS. However, this therapy possibly reduces insulin sensitivity.

PMID:
25523572
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Chinese Journal of Contemporary Pediatrics
Loading ...
Support Center