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Head Neck. 2016 May;38(5):769-74. doi: 10.1002/hed.23958. Epub 2015 Jun 20.

Detection of Helicobacter pylori in patients with head and neck cancer: Results from a prospective comparative study combining serology, polymerase chain reaction, and rapid urease test.

Author information

1
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich, Switzerland.
2
Institute of Surgical Pathology, University Hospital Zurich, Switzerland.
3
Institute of Medical Microbiology, University of Zurich, Switzerland.

Abstract

BACKGROUND:

The purpose of this study was to evaluate prospectively the presence and impact of the gastric carcinogen Helicobacter pylori (H. pylori) in the upper aerodigestive tract. Previous studies suggested it could represent a risk factor for head and neck squamous cell carcinoma (HNSCC).

METHODS:

Serology, rapid urease test, and quantitative polymerase chain reaction (qPCR) for H. pylori were performed in patients with head and neck cancer (N = 56) and cancer-free controls (N = 90). Comparison between groups was done using logistic regression analysis.

RESULTS:

Rates of positive serology and rapid urease test did not differ between the 2 groups in logistic regression analysis (p = .677 and p = .633, respectively). Birth in a developing country and age above 50 years old were predictors of positive serology (p < .001 and p = .040, respectively). Using qPCR, no biopsy showed the presence of H. pylori.

CONCLUSION:

This study challenges the concept that H. pylori may be a risk factor for HNSCC.

KEYWORDS:

head and neck cancer; helicobacter pylori; polymerase chain reaction (PCR); rapid urease test; serology

PMID:
25522348
DOI:
10.1002/hed.23958
[Indexed for MEDLINE]
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