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Leuk Res. 1989;13(9):745-55.

Induction of aplastic anemia by intra-bone marrow inoculation of a molecularly cloned feline retrovirus.

Author information

1
Department of Pathology, Colorado State University, Fort Collins 80523.

Abstract

Intra-bone marrow inoculation of cells infected with molecularly cloned feline retrovirus (FeLV-C-Sarma [FSC]) associated with aplastic anemia was examined to test the hypothesis that cell-to-cell transmission of virus might facilitate marrow cell infection and anemogenesis, a possibility suggested by in-vitro co-culture experiments. IBM inoculation of either FSC-infected feline marrow cells or fibroblasts of weanling cats bypassed age-related restriction of FSC replication, initiated viremia, caused irreversible depletion of erythroid burst forming units, and induced rapid fatal aplastic anemia. A second significant finding observed with FSC infection was pronounced systemic lymphoid depletion. The direct bone marrow inoculation system described facilitates experimental study of retrovirus-target cell interactions involved in erythroid aplasia.

PMID:
2552228
DOI:
10.1016/0145-2126(89)90087-8
[Indexed for MEDLINE]

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