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Expert Rev Clin Immunol. 2015 Jan;11(1):155-65. doi: 10.1586/1744666X.2015.995097. Epub 2014 Dec 18.

STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?

Author information

1
Cancer immunology, Inflammation and Tolerance Program, Cancer Center, Georgia Regents University, 1120 15th St, Augusta GA 30912, USA.

Abstract

DNA has potent immunogenic properties that are useful to enhance vaccine efficacy. DNA also incites hyperinflammation and autoimmunity if DNA sensing is not regulated. Paradoxically, DNA regulates immunity and autoimmunity when administered systemically as DNA nanoparticles. DNA nanoparticles regulated immunity via cytosolic DNA sensors that activate the signaling adaptor stimulator of interferon genes. In this review, we describe how DNA sensing to activate stimulator of interferon genes promotes regulatory responses and discuss the biological and clinical implications of these responses for understanding disease progression and designing better therapies for patients with chronic inflammatory diseases, such as autoimmune syndromes or cancer.

KEYWORDS:

DNA; STING; autoimmunity; cancer; immunity; immunotherapy; nanoparticles; tolerance

PMID:
25521938
PMCID:
PMC4387570
DOI:
10.1586/1744666X.2015.995097
[Indexed for MEDLINE]
Free PMC Article

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