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Nat Immunol. 2015 Jan;16(1):27-35. doi: 10.1038/ni.3045.

Respiratory epithelial cells orchestrate pulmonary innate immunity.

Author information

1
Perinatal Institute, Division of Neonatology, Division of Perinatal Biology and Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
2
Division of Immunobiology, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Abstract

The epithelial surfaces of the lungs are in direct contact with the environment and are subjected to dynamic physical forces as airway tubes and alveoli are stretched and compressed during ventilation. Mucociliary clearance in conducting airways, reduction of surface tension in the alveoli, and maintenance of near sterility have been accommodated by the evolution of a multi-tiered innate host-defense system. The biophysical nature of pulmonary host defenses are integrated with the ability of respiratory epithelial cells to respond to and 'instruct' the professional immune system to protect the lungs from infection and injury.

PMID:
25521682
PMCID:
PMC4318521
DOI:
10.1038/ni.3045
[Indexed for MEDLINE]
Free PMC Article
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