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J Perinatol. 2015 May;35(5):379-83. doi: 10.1038/jp.2014.222. Epub 2014 Dec 18.

Outcomes of extremely preterm infants after delivery room cardiopulmonary resuscitation in a population-based cohort.

Author information

1
Department of Pediatrics, University of California, San Francisco, CA, USA.
2
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
3
Department of Pediatrics, Stanford University, California Perinatal Quality Care Collaborative, Stanford, CA, USA.

Abstract

OBJECTIVE:

To describe the relationship of delivery room cardiopulmonary resuscitation (DR-CPR) to short-term outcomes of extremely preterm infants.

STUDY DESIGN:

This was a cohort study of 22 to 27+6/7 weeks gestational age (GA) infants during 2005 to 2011. DR-CPR was defined as chest compressions and/or epinephrine administration. Multivariable logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) associated with DR-CPR; analysis was stratified by GA.

RESULT:

Of the 13‚ÄČ758 infants, 856 (6.2%) received DR-CPR. Infants 22 to 23+6/7 weeks receiving DR-CPR had similar outcomes to non-recipients. Infants 24 to 25+6/7 weeks receiving DR-CPR had more severe intraventricular hemorrhage (OR 1.36, 95% CI 1.07, 1.72). Infants 26 to 27+6/7 weeks receiving DR-CPR were more likely to die (OR 1.81, 95% CI 1.30, 2.51) and have intraventricular hemorrhage (OR 2.10, 95% CI 1.56, 2.82). Adjusted hospital DR-CPR rates varied widely (median 5.7%).

CONCLUSION:

Premature infants receiving DR-CPR had worse outcomes. Mortality and morbidity varied by GA.

PMID:
25521563
PMCID:
PMC4414658
DOI:
10.1038/jp.2014.222
[Indexed for MEDLINE]
Free PMC Article

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