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Adv Mater. 2015 Mar 4;27(9):1567-72. doi: 10.1002/adma.201404896. Epub 2014 Dec 17.

Spatially gradated hydrogel platform as a 3D engineered tumor microenvironment.

Author information

1
The Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, Illinois, 61801, USA.

Abstract

There is an acute need for biomaterial tools that recreate the heterogeneous brain-tumor microenvironment. A microfluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor-inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the potential for clinical insight.

KEYWORDS:

glioblastoma; gradient; hydrogel; microfluidics; tumor microenvironment

PMID:
25521283
DOI:
10.1002/adma.201404896
[Indexed for MEDLINE]

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