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Diabetes Care. 2015 Feb;38(2):329-32. doi: 10.2337/dc14-0850. Epub 2014 Dec 17.

Early childhood gut microbiomes show strong geographic differences among subjects at high risk for type 1 diabetes.

Collaborators (246)

Rewers M, Barriga K, Bautista K, Baxter J, Eisenbarth G, Frank N, Bedoy R, Gesualdo P, Hoffman M, Ide L, Karban R, Liu E, Norris J, Waugh K, Samper-Imaz A, Steck A, She JX, Schatz D, Hopkins D, Steed L, Thomas J, Silvis K, Haller M, Shankar M, Sheehan E, Gardiner M, McIndoe R, Liu H, Nechtman J, Sharma A, Williams J, Foghis G, Anderson SW, Ziegler AG, Beyerlein A, Bonifacio E, Henneberger L, Hummel M, Hummel S, Foterek K, Kersting M, Knopff A, Koletzko S, Krause S, Peplow C, Pflüger M, Roth R, Schenkel J, Stock J, Strauss E, Warncke K, Winkler C, Simell OG, Toppari J, Adamsson A, Hyöty H, Ilonen J, Kähönen M, Knip M, Koivu A, Koreasalo M, Kurppa K, Lönnrot M, Mäntymäki E, Multasuo K, Mykkänen J, Niininen T, Nanto-Salonen K, Nyblom M, Rautanen J, Riikonen A, Romo M, Simell A, Simell B, Simell S, Simell T, Simell V, Sjöberg M, Stenius S, Varjonen E, Veijola R, Virtanen SM, Åkerlund M, Lernmark Å, Agardh D, Aronsson CA, Ask M, Bremer J, Carlsson UM, Cilio C, Ekstrand C, Ericson-Hallström E, Fransson L, Gard T, Gerardsson J, Håkansson R, Hansen M, Hansson G, Hyberg S, Johansen F, Jonasdottir B, Jonsson L, Larsson H, Lernmark B, Månsson-Martinez M, Markan M, Massadakis T, Melin J, Mestan Z, Nilsson A, Rahmati K, Ramelius A, Järvirova MS, Sibthorpe S, Sjöberg B, Swartling U, Trulsson E, Törn C, Wallin A, Wimar Å, Åberg S, Hagopian WA, Yan X, Killian M, Crouch CC, Hay KM, Skidmore J, Adams C, Ayres S, Bratrude B, Coughlin D, Fowler G, Franco C, Hammar C, Dunson K, Heaney D, Hervey R, Kindschi R, Marcus P, Meyer A, Mulenga D, Scott E, Stabbert J, Stepitova V, Williams N, Willis J, Becker D, Franciscus M, Smith MD, Daftary A, Klein MB, Krischer JP, Abbondondolo M, Austin-Gonzalez S, Brown R, Burkhardt B, Butterworth M, Cuthbertson D, Eberhard C, Fiske S, Garcia D, Gowda V, Hadley D, Lee HS, Liu S, Liu X, Lynch K, Malloy J, McCarthy C, McLeod W, Shaffer C, Smith L, Smith S, Tamura R, Uusitalo U, Vehik K, Washington E, Yang J, Akolkar B, Bourcier K, Briese T, Johnson SB, Oberste S, Triplett E, Yu L, Miao D, Bingley P, Williams A, Chandler K, Rokni S, Long A, Boldison J, Butterly J, Broadhurst J, Carreno G, Caygill C, Curnock R, Easton P, Geoghan I, Goode J, Long A, Payne M, Pearson J, Reed C, Ridewood S, Wyatt R, Eriksson EA, Karlsson EL, Erlund I, Salminen I, Sundvall J, Leiviskä J, Lehtonen M, Little RR, Tennill AL, Erlich H, Mack SJ, Fear AL, Bugawan T, Alejandrino M, Fiehn O, Wikoff B, Kind T, Palazoglu M, Wong J, Wohlgemuth G, Petrosino JF, Marcovina SM, Gaur VP, Smith R, Metz T, Higgins H, Ke S, She JX, McIndoe R, Liu H, Nechtman J, Zhao Y, Jiang N, Rich SS, Chen WM, Onengut-Gumuscu S, Farber E, Pickin RR, Davis J, Gallo D.

Author information

1
Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL.
2
Department of Mathematics, University of Louisiana at Lafayette, Lafayette, LA.
3
Health Informatics Institute, University of South Florida, Tampa, FL.
4
Department of Statistics, University of Florida, Gainesville, FL.
5
Department of Pediatrics, Turku University Hospital, University of Turku, Turku, Finland.
6
Institute of Diabetes Research, Helmholtz Zentrum München, and Klinikum Rechts der Isar, Technische Universität München, and Forschergruppe Diabetes e.V., Neuherberg, Germany.
7
Barbara Davis Center for Diabetes, School of Medicine, University of Colorado, Aurora, CO.
8
Department of Clinical Sciences, Lund University/Clinical Research Center, Skåne University Hospital, Malmö, Sweden.
9
Pacific Northwest Diabetes Research Institute, Seattle, WA.
10
Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Georgia Regents University, Augusta, GA.
11
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
12
Department of Pediatrics, College of Medicine, University of Florida, Gainesville, FL.
13
Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL.
14
Department of Microbiology and Cell Science, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL ewt@ufl.edu.

Abstract

OBJECTIVE:

Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes.

RESEARCH DESIGN AND METHODS:

High-throughput 16S rRNA sequencing was performed on stool samples collected from 90 high-risk, nonautoimmune infants participating in The Environmental Determinants of Diabetes in the Young (TEDDY) study in the U.S., Germany, Sweden, and Finland.

RESULTS:

Study site-specific patterns of gut colonization share characteristics across continents. Finland and Colorado have a significantly lower bacterial diversity, while Sweden and Washington state are dominated by Bifidobacterium in early life. Bacterial community diversity over time is significantly different by geographical location.

CONCLUSIONS:

The microbiome of high-risk infants is associated with geographical location. Future studies aiming to identify the microbiome disease phenotype need to carefully consider the geographical origin of subjects.

PMID:
25519450
PMCID:
PMC4302256
DOI:
10.2337/dc14-0850
[Indexed for MEDLINE]
Free PMC Article

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