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Nat Commun. 2014 Dec 18;5:5861. doi: 10.1038/ncomms6861.

Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle.

Author information

1
1] Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads, Newstead, Hamilton 3240, New Zealand [2] School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.
2
School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1010, New Zealand.
3
Livestock Improvement Corporation, Cnr Ruakura and Morrinsville Roads, Newstead, Hamilton 3240, New Zealand.
4
Unit of Animal Genomics, GIGA-R, Faculty of Veterinary Medicine, University of Liège (B34), Liège B-4000, Belgium.
5
Department of Animal, Rangeland and Wildlife Sciences, Texas A&M University-Kingsville, MSC 228, Kingsville, Texas 78363-8202, USA.
6
Department of Agriculture and Environmental Science, Lincoln University, 820 Chestnut Street, Jefferson City, Missouri 65101, USA.
7
Department of Animal Science, Iowa State University, 225 Kildee, Ames, Iowa 50011-3250, USA.

Abstract

Lactation, hair development and homeothermy are characteristic evolutionary features that define mammals from other vertebrate species. Here we describe the discovery of two autosomal dominant mutations with antagonistic, pleiotropic effects on all three of these biological processes, mediated through the prolactin signalling pathway. Most conspicuously, mutations in prolactin (PRL) and its receptor (PRLR) have an impact on thermoregulation and hair morphology phenotypes, giving prominence to this pathway outside of its classical roles in lactation.

PMID:
25519203
PMCID:
PMC4284646
DOI:
10.1038/ncomms6861
[Indexed for MEDLINE]
Free PMC Article

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