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Radiat Oncol. 2014 Dec 18;9:266. doi: 10.1186/s13014-014-0266-7.

Endothelial perturbations and therapeutic strategies in normal tissue radiation damage.

Korpela E1,2, Liu SK3,4,5.

Author information

1
Biological Sciences, Sunnybrook Research Institute and Odette Cancer Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Toronto, M4N 3M5, Canada. elina.korpela@mail.utoronto.ca.
2
Department of Medical Biophysics, University of Toronto, 101 College St., Toronto, M5G 1L7, Canada. elina.korpela@mail.utoronto.ca.
3
Biological Sciences, Sunnybrook Research Institute and Odette Cancer Centre, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Toronto, M4N 3M5, Canada. stanley.liu@sunnybrook.ca.
4
Department of Medical Biophysics, University of Toronto, 101 College St., Toronto, M5G 1L7, Canada. stanley.liu@sunnybrook.ca.
5
Department of Radiation Oncology, University of Toronto, 149 College St., Toronto, M5T 1P5, Canada. stanley.liu@sunnybrook.ca.

Abstract

Most cancer patients are treated with radiotherapy, but the treatment can also damage the surrounding normal tissue. Radiotherapy side-effects diminish patients' quality of life, yet effective biological interventions for normal tissue damage are lacking. Protecting microvascular endothelial cells from the effects of irradiation is emerging as a targeted damage-reduction strategy. We illustrate the concept of the microvasculature as a mediator of overall normal tissue radiation toxicity through cell death, vascular inflammation (hemodynamic and molecular changes) and a change in functional capacity. Endothelial cell targeted therapies that protect against such endothelial cell perturbations and the development of acute normal tissue damage are mostly under preclinical development. Since acute radiation toxicity is a common clinical problem in cutaneous, gastrointestinal and mucosal tissues, we also focus on damage in these tissues.

PMID:
25518850
PMCID:
PMC4279961
DOI:
10.1186/s13014-014-0266-7
[Indexed for MEDLINE]
Free PMC Article

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