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J Med Assoc Thai. 2014 Feb;97 Suppl 2:S196-201.

Xanthones from mangosteen (Garcinia mangostana): multi-targeting pharmacological properties.

Abstract

OBJECTIVE:

This review focuses on mangosteen pericarp extracts, xanthones and derivatives for the future laboratory experiment and development in pharmacological aspects.

MATERIAL AND METHOD:

All relevant literature databases were searched up to 2 March 2014. The search terms included mangosteen, xanthone, mangostin, and gatanin in all of the human, animal, in vitro and in vivo studies. Anti-intflammation, antioxidant, antibacterial, anticancer and antiulcer properties of each substance were the key parameters.

RESULTS:

Xanthones are a group of oxygen-containing heterocyclic compounds including alpha-mangostin, gamma-mangostin, mangosteen extract, xanthone derivatives and synthetic xanthones, which provide remarkable and diverse pharmacological effects such as anticancer, antioxidant, anti-inflammatory and antimicrobial activities.

CONCLUSION:

These xanthone compounds may play a major role in therapeutic treatment ofthe diseases but precise mechanisms ofaction are still unclear and needfurther investigation.

PMID:
25518194
[Indexed for MEDLINE]

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