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Future Microbiol. 2014;9(12):1361-72. doi: 10.2217/fmb.14.89.

Hepatitis E in developed countries: current status and future perspectives.

Author information

1
Cornwall Gastrointestinal Unit, Royal Cornwall Hospital & European Centre for the Environment & Human Health, University of Exeter Medical School, Truro TR1 3LJ, UK.

Abstract

Hepatitis E virus (HEV) was for many years thought to be found almost exclusively in developing countries, where it is a major health issue. Recent studies have shown that HEV causes acute and chronic infection in developed countries. In these geographical settings, HEV is primarily a porcine zoonosis caused by genotypes 3 (HEV3) and 4 (HEV4). The clinical phenotype of hepatitis E continues to emerge, and recent data show that HEV is associated with a range of neurological syndromes including Guillain-Barré syndrome and neuralgic amytrophy.

KEYWORDS:

chronic infection; cirrhosis; hepatitis; hepatitis E; pigs; zoonosis

PMID:
25517900
DOI:
10.2217/fmb.14.89
[Indexed for MEDLINE]

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