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Cancer Cell. 2014 Nov 10;26(5):601-3. doi: 10.1016/j.ccell.2014.10.011. Epub 2014 Nov 10.

mTORC1 gRABs the Golgi.

Author information

1
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
2
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA. Electronic address: david.guertin@umassmed.edu.

Abstract

A lysosome-based mechanism of amino acid sensing by mTORC1 regulated by Rag GTPases has emerged. In this issue of Cancer Cell, Thomas and colleagues propose a Golgi-based and Rag-independent mechanism mediated by the Rab1A GTPase. Furthermore, Rab1A overexpression in colorectal cancers correlates with mTORC1 activity and sensitivity to mTOR inhibitors.

PMID:
25517745
DOI:
10.1016/j.ccell.2014.10.011
[Indexed for MEDLINE]
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