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Acta Cir Bras. 2014 Dec;29(12):776-80. doi: 10.1590/S0102-86502014001900002.

Attenuation of copaiba oil in hepatic damage in rats.

Author information

1
Department of Integrate Health, Medical School, Para State University, Belem, PA, Brazil.
2
School of Medicine, UEPA, Brazil.
3
School of Medicine, UEPA, Belem, PA, Brazil.
4
Medical School, UEPA, Belem, PA, Brazil.

Abstract

PURPOSE:

To investigate the copaiba oil on the hepatic damage induced by acetaminophen, comparing against corn oil.

METHODS:

Fifty four rats were distributed into nine study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours after the acetaminophen, the corn's groups were similar than copaiba oil groups; and N-Acetyl-Cysteine Group, that received the N-Acetyl-Cysteine two hours after the acetaminophen. Euthanasia was performed after 24 hours. The serum levels transaminases, bilirubin and canalicular enzymes were analyzed.

RESULTS:

The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 and corn's groups showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and ɤ GT (p>0.05). The therapy copaiba group showed the highest levels of total bilirubin and was statistically different from the other groups (p<0.01).

CONCLUSIONS:

Copaiba oil administered prophylactically for seven days and therapeutically 2 hours after the acetaminophen acute intoxication offered a potential hepato protection against paracetamol-induced hepatic damage, normalizing the biochemical parameters similarly to N-Acetyl-Cysteine, and the treatment with corn oil shows no effect on the liver damage.

PMID:
25517489
DOI:
10.1590/S0102-86502014001900002
[Indexed for MEDLINE]
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