Format

Send to

Choose Destination
Nat Chem Biol. 2015 Jan;11(1):9-15. doi: 10.1038/nchembio.1712.

Targeting mitochondria metabolism for cancer therapy.

Author information

1
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Abstract

Mitochondria have a well-recognized role in the production of ATP and the intermediates needed for macromolecule biosynthesis, such as nucleotides. Mitochondria also participate in the activation of signaling pathways. Overall, accumulating evidence now suggests that mitochondrial bioenergetics, biosynthesis and signaling are required for tumorigenesis. Thus, emerging studies have begun to demonstrate that mitochondrial metabolism is potentially a fruitful arena for cancer therapy. In this Perspective, we highlight recent developments in targeting mitochondrial metabolism for the treatment of cancer.

PMID:
25517383
PMCID:
PMC4340667
DOI:
10.1038/nchembio.1712
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center