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Curr Biol. 2014 Nov 3;24(21):R1046-8. doi: 10.1016/j.cub.2014.09.079. Epub 2014 Nov 3.

Centriole duplication: when PLK4 meets Ana2/STIL.

Author information

1
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
2
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
3
Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address: tsoum@mskcc.org.

Abstract

Polo-like kinase 4 is known to drive centriole duplication, but the relevant substrate remains elusive. A new study shows that PLK4 phosphorylates a key centriolar component, Ana2/STIL, to initiate centriole assembly.

PMID:
25517369
DOI:
10.1016/j.cub.2014.09.079
[Indexed for MEDLINE]
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