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Curr Opin Endocrinol Diabetes Obes. 2015 Feb;22(1):48-54. doi: 10.1097/MED.0000000000000127.

Cushing's syndrome in childhood: update on genetics, treatment, and outcomes.

Author information

1
Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.

Abstract

PURPOSE OF REVIEW:

To provide an update on the genes associated with Cushing's syndrome in children, as well as to familiarize the clinician with recent treatment guidelines and outcome data for children with Cushing's syndrome.

RECENT FINDINGS:

The list of genes associated with Cushing's syndrome continues to grow. In addition, treatment for childhood Cushing's syndrome is evolving. As long-term follow-up data on children becomes available, clinicians need to be aware of the issues that require attention.

SUMMARY:

Knowledge of the specific genetic causes of Cushing's syndrome has potential implications for treatment, surveillance, and counseling. Advances in surgical technique, radiation modalities, and medical therapies offer the potential for additional treatment options in Cushing's syndrome. Early identification and management of post-treatment morbidities in children treated for Cushing's syndrome is crucial in order to optimize care.

PMID:
25517021
PMCID:
PMC4415092
DOI:
10.1097/MED.0000000000000127
[Indexed for MEDLINE]
Free PMC Article

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