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Biosci Biotechnol Biochem. 2015;79(4):636-9. doi: 10.1080/09168451.2014.991683. Epub 2014 Dec 17.

Perfluorooctanoic acid binds to peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation in 3T3-L1 adipocytes.

Author information

1
a Faculty of Applied Bioscience, Department of Nutritional Science , Tokyo University of Agriculture , Tokyo , Japan.

Abstract

We examined the effect of perfluorooctanoic acid (PFOA) on adipose cells using 3T3-L1 adipocytes and found that PFOA increased adipocyte differentiation, triglyceride accumulation, and the mRNA level of factors related to adipocyte differentiation. In addition, PFOA bound to peroxisome proliferator-activated receptor γ (PPAR γ). These results suggest that PFOA promotes adipocyte differentiation as a PPAR γ ligand.

KEYWORDS:

3T3-L1 adipocyte; adipocyte differentiation; perfluorooctanoic acid; peroxisome proliferator-activated receptor γ

PMID:
25516096
DOI:
10.1080/09168451.2014.991683
[Indexed for MEDLINE]

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