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Nat Prod Res. 2015;29(22):2137-40. doi: 10.1080/14786419.2014.991927. Epub 2014 Dec 17.

Alkaloid extracts of Ficus species and palm oil-derived tocotrienols synergistically inhibit proliferation of human cancer cells.

Author information

1
a Faculty of Science, School of Biosciences, The University of Nottingham Malaysia Campus , Jalan Broga, 43500 Semenyih , Selangor , Malaysia.
2
b Faculty of Science, School of Pharmacy, The University of Nottingham Malaysia Campus , Jalan Broga, 43500 Semenyih , Selangor , Malaysia.
3
c Biotechnology Research Centre, The University of Nottingham Malaysia Campus , Jalan Broga, 43500 Semenyih , Selangor , Malaysia.

Abstract

Tocotrienols have been reported to possess anticancer effects other than anti-inflammatory and antioxidant activities. This study explored the potential synergism of antiproliferative effects induced by individual alkaloid extracts of Ficus fistulosa, Ficus hispida and Ficus schwarzii combined with δ- and γ-tocotrienols against human brain glioblastoma (U87MG), lung adenocarcinoma (A549) and colorectal adenocarcinoma (HT-29) cells. Cell viability and morphological results demonstrated that extracts containing a mixture of alkaloids from the leaves and bark of F. schwarzii inhibited the proliferation of HT-29 cells, whereas the alkaloid extracts of F. fistulosa inhibited the proliferation of both U87MG and HT-29 cells and showed synergism in combined treatments with either δ- or γ-tocotrienol resulting in 2.2-34.7 fold of reduction in IC50 values of tocotrienols. The observed apoptotic cell characteristics in conjunction with the synergistic antiproliferative effects of Ficus species-derived alkaloids and tocotrienols assuredly warrant future investigations towards the development of a value-added chemotherapeutic regimen against cancers.

KEYWORDS:

Ficus fistulosa; Ficus hispida; Ficus schwarzii; antiproliferative; cancer cells; synergism; tocotrienols

PMID:
25515603
DOI:
10.1080/14786419.2014.991927
[Indexed for MEDLINE]

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