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Bioanalysis. 2015;7(6):653-9. doi: 10.4155/bio.14.310. Epub 2014 Dec 16.

A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated blood hematocrit.

Author information

1
Bioanalytical Science & Toxicokinetics, Drug Metabolism & Pharmacokinetics, GlaxoSmithKline Research & Development, Ware, UK.

Abstract

AIMS:

A cross-laboratory experiment has been performed on a novel dried blood sampler in order to investigate whether it overcomes issues associated with blood volume and hematocrit (HCT) that are observed when taking a subpunch from dried blood spot samples.

MATERIALS & METHODS:

An average blood volume of 10.6 μl was absorbed by the samplers across the different HCTs investigated (20-65%).

RESULTS:

No notable change of volume absorbed was noted across the HCT range. Furthermore, the variation in blood sample volumes across six different laboratories was within acceptable limits.

CONCLUSION:

The novel volumetric absorptive microsampling device has the potential to deliver the advantages of dried blood spot sampling while overcoming some of the issues associated with the technology.

PMID:
25514576
DOI:
10.4155/bio.14.310
[Indexed for MEDLINE]
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