Format

Send to

Choose Destination
Molecules. 2014 Dec 12;19(12):20864-79. doi: 10.3390/molecules191220864.

Relevance of the anti-inflammatory properties of curcumin in neurodegenerative diseases and depression.

Author information

1
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA. ytizabi@howard.edu.
2
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA. laura.hurley@students.mq.edu.au.
3
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA. quallszm@njms.rutgers.edu.
4
Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, USA. lra28@georgetown.edu.

Abstract

This review is an attempt to summarize our current understanding of curcumin's potential as a neuroprotectant and an antidepressant. This dual property confers a unique advantage to this herbal medication, believed to be devoid of any major side effects, to combat commonly observed co-morbid conditions of a neurodegenerative and a neuropsychiatric disorder. Moreover, in line with the theme of this series, the role of inflammation and stress in these diseases and possible anti-inflammatory effects of curcumin, as well as its interaction with signal transduction proteins as a common denominator in its varied mechanisms of action, are also discussed. Thus, following a brief introduction of curcumin's pharmacology, we present research suggesting how its anti-inflammatory properties have therapeutic potential in treating a devastating neurological disorder (Parkinson's disease = PD) and a debilitating neuropsychiatric disorder (major depressive disorder = MDD). It is concluded that curcumin, or better yet, an analog with better and longer bioavailability could be of important therapeutic potential in PD and/or major depression.

PMID:
25514226
PMCID:
PMC6270664
DOI:
10.3390/molecules191220864
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center