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Respir Physiol Neurobiol. 2015 Feb 1;207:22-7. doi: 10.1016/j.resp.2014.12.009. Epub 2014 Dec 13.

Inspiratory resonant frequency of forced oscillation technique as a predictor of the composite physiologic index in interstitial lung disease.

Author information

1
Department of Respiratory Medicine, Shizuoka General Hospital, 4-27-1 Kita-Ando, Aoi, Shizuoka, 420-8527, Japan. Electronic address: mfujii74@gmail.com.
2
Department of Respiratory Medicine, Shizuoka General Hospital, 4-27-1 Kita-Ando, Aoi, Shizuoka, 420-8527, Japan. Electronic address: toshihiro-shirai@i.shizuoka-pho.jp.
3
Second Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address: mori.kazutaka@gmail.com.
4
Second Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address: masa.mikam@gmail.com.
5
Department of Respiratory Medicine, Shizuoka General Hospital, 4-27-1 Kita-Ando, Aoi, Shizuoka, 420-8527, Japan. Electronic address: sisidiba@gmail.com.
6
Department of Respiratory Medicine, Shizuoka General Hospital, 4-27-1 Kita-Ando, Aoi, Shizuoka, 420-8527, Japan. Electronic address: takefumi-akita@i.shizuoka-pho.jp.
7
Department of Respiratory Medicine, Shizuoka General Hospital, 4-27-1 Kita-Ando, Aoi, Shizuoka, 420-8527, Japan. Electronic address: cqn00563@nifty.com.
8
Department of Respiratory Medicine, Shizuoka General Hospital, 4-27-1 Kita-Ando, Aoi, Shizuoka, 420-8527, Japan. Electronic address: kazuhiro-asada@i.shizuoka-pho.jp.
9
Second Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address: suda@hama-med.ac.jp.

Abstract

The composite physiologic index (CPI), which is derived from FEV1, FVC, and diffusing capacity, has been developed to predict the extent of fibrosis on high-resolution computed tomography (HRCT). However, the relevance to the forced oscillation technique (FOT) is not fully understood. We hypothesized that FOT would independently predict the CPI in interstitial lung disease (ILD). In this cross-sectional study we assessed the relationship between pulmonary function tests, forced oscillatory parameters, and the degree of fibrosis in ILD. Spirometry, evaluation of diffusing capacity for carbon monoxide, and the broadband frequency FOT were performed in 93 patients with a clinical/HRCT diagnosis of ILD. The CPI was calculated and fibrosis extent was measured by HRCT and scored. Univariate analyses revealed that, of the forced oscillatory parameters, inspiratory resonant frequency best correlated with FVC, FEV1, diffusing capacity, CPI, and fibrosis score. In multiple regression analyses, CPI was independently predicted by inspiratory resonant frequency and fibrosis score (model R(2)=0.405, p<0.0001).

KEYWORDS:

Composite physiologic index; Fibrosis; Forced oscillation technique; Interstitial lung disease; Resonant frequency

PMID:
25514184
DOI:
10.1016/j.resp.2014.12.009
[Indexed for MEDLINE]

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