Format

Send to

Choose Destination
J Ther Ultrasound. 2013 Oct 1;1:18. doi: 10.1186/2050-5736-1-18. eCollection 2013.

Effects of varying duty cycle and pulse width on high-intensity focused ultrasound (HIFU)-induced transcranial thrombolysis.

Author information

1
Brain Ultrasound Research Laboratory (BURL), Department of Radiology, University of California San Diego, San Diego, CA, 92103, USA ; Department of Neurosciences, University of California San Diego, 200 West Arbor Drive, San Diego, CA, 92103-8756, USA.
2
Division of Biostatistics and Bioinformatics, University of California San Diego, San Diego, CA, 92093, USA.
3
Brain Ultrasound Research Laboratory (BURL), Department of Radiology, University of California San Diego, San Diego, CA, 92103, USA.
4
InSightec, Ltd, 5 Nahum Heth St., Tirat Carmel, 39120, Israel.

Abstract

The goal was to test the effects of various combinations of pulse widths (PW) and duty cycles (DC) on high-intensity focused ultrasound (HIFU)-induced sonothrombolysis efficacy using an in vitro flow model. An ExAblate™ 4000 HIFU headsystem (InSightec, Inc., Israel) was used. Artificial blood clots were placed into test tubes inside a human calvarium and exposed to pulsatile flow. Four different duty cycles were tested against four different pulse widths. For all study groups, an increase in thrombolysis efficacy could be seen in association with increasing DC and/or PW (p < 0.0001). Using transcranial HIFU, significant thrombolysis can be achieved within seconds and without the use of lytic drugs in vitro. Longer duty cycles in combination with longer pulse widths seem to have the highest potential to optimize clot lysis efficacy.

KEYWORDS:

Duty cycle; High-intensity focused ultrasound; Pulse width; Stroke; Thrombolysis; Transcranial

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center