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Med Intensiva. 2015 Apr;39(3):167-71. doi: 10.1016/j.medin.2014.09.008. Epub 2014 Dec 13.

New oral anticoagulants in severe trauma patients: enemy at the gates?

[Article in English, Spanish]

Author information

Unidad de Neurocríticos. Unidad de Gestión Clínica de Cuidados Críticos y Urgencias, Hospital Universitario Virgen del Rocío, Sevilla, España; Instituto de Biomedicina de Sevilla (IBiS)/CSIC/Universidad de Sevilla, Sevilla, España. Electronic address:
Departamento de Urgencias, Hospital Universitario La Paz, IdiPAZ, Madrid, España; Unidad de Cuidados Intensivos, Hospital Universitario La Paz, IdiPAZ, Madrid, España.


The high incidence of trauma, especially in elderly people anticoagulated with new oral anticoagulants (NOAs), has become a major challenge, particularly in critical situations with life-threatening bleeding. Under these circumstances, urgent NOA reversion becomes mandatory. Prothrombin complex has become a frequent indication in critical situations in which rapid reversal of anticoagulation is needed and where the use of fresh frozen plasma is limited. This study offers our point of view regarding the usefulness of NOAs, not only in the prevention of cardioembolic events but also as regards their emergent reversion in cases of severe bleeding associated to trauma.


Bleeding; Complejo concentrado de protrombina; Hemorragia; New oral anticoagulants; Nuevos anticoagulantes orales; Prothrombin complex concentrate; Reversion; Reversión; Trauma

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