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Alzheimers Dement. 2015 Jun;11(6):710-7. doi: 10.1016/j.jalz.2014.10.008. Epub 2014 Dec 12.

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease.

Author information

1
Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA. Electronic address: hsnyder@alz.org.
2
National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
3
Department of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
4
Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
5
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
6
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
7
Department of Neurosciences, Cleveland Clinic, Cleveland, OH, USA.
8
Department of Pathology, University of Washington, Seattle, WA, USA.
9
Division of Glial Disease and Therapeutics, University of Rochester Medical Center, Rochester, NY, USA.
10
Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
11
Departments of Pathology and Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
12
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
13
Department of Physiology, University of Kentucky, Lexington, KY, USA.
14
Departments of Neurological Surgery and Neurology, Washington University, St Louis, St Louis, MO, USA.
15
Department of Physiology, University of Southern California, Los Angeles, CA, USA.
16
Independent Science Writer, Elverson, PA, USA.
17
National Institute of Heart, Lung and Blood, National Institutes of Health, Bethesda, MD, USA.
18
Medical & Scientific Relations, Alzheimer's Association, Chicago, IL, USA.

Abstract

Scientific evidence continues to demonstrate the linkage of vascular contributions to cognitive impairment and dementia such as Alzheimer's disease. In December, 2013, the Alzheimer's Association, with scientific input from the National Institute of Neurological Disorders and Stroke and the National Heart, Lung and Blood Institute from the National Institutes of Health, convened scientific experts to discuss the research gaps in our understanding of how vascular factors contribute to Alzheimer's disease and related dementia. This manuscript summarizes the meeting and the resultant discussion, including an outline of next steps needed to move this area of research forward.

KEYWORDS:

Alzheimer's disease; Animal models; Biomarkers; Dementia; Small vessel disease; Vascular dementia

PMID:
25510382
PMCID:
PMC4731036
DOI:
10.1016/j.jalz.2014.10.008
[Indexed for MEDLINE]
Free PMC Article

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