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Ann Hum Biol. 2016;43(1):91-5. doi: 10.3109/03014460.2014.968619. Epub 2014 Dec 16.

Inflammation and weight gain in reproductive-aged women.

Author information

1
a Obesity Prevention Program in the Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute , Boston , MA , USA .
2
b Connors Center for Women's Health, Brigham and Women's Hospital , Boston , MA , USA , and.
3
c Obstetrics and Gynecology, University of North Carolina School of Medicine , Chapel Hill , NC , USA.

Abstract

AIM:

To investigate whether mid-pregnancy inflammation predicts the rate of subsequent gestational weight gain (GWG) and whether inflammation at 3 years post-partum is associated with weight and waist circumference (WC) gain during a median of 4.4 years follow-up.

SUBJECTS AND METHODS:

This study quantified CRP, IL-6 and TNF-α in plasma of 886 women at ∼28 weeks gestation and calculated GWG rate (kg/week) from blood draw to delivery. At ∼3 years post-partum, CRP and IL-6 were assessed from 351 women and weight and WC were measured at 3 and 7 years post-partum. This study used linear regression to investigate the relationship between mid-pregnancy inflammation and subsequent GWG rate and the association of inflammation at 3 years post-partum with weight and WC change during follow-up.

RESULTS:

After accounting for confounders, a small dose-response association of mid-gestation CRP with subsequent GWG was observed; women in the 4th CRP quartile gained weight at 0.05 (95% CI = 0.01, 0.10) kg/week faster than those in the 1st quartile. Neither IL-6 nor TNF-α was related to GWG. Post-partum inflammation was not associated with subsequent weight or WC gain.

CONCLUSIONS:

Higher mid-gestation CRP was related to modestly higher subsequent GWG rate. Future studies are warranted to confirm these findings.

KEYWORDS:

C-reactive protein; gestational weight gain; inflammation; longitudinal; reproductive-aged women

PMID:
25510294
PMCID:
PMC5076557
DOI:
10.3109/03014460.2014.968619
[Indexed for MEDLINE]
Free PMC Article

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